Evidence on the Carcinogenicity of Sodium Saccharin
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P-76: Effects of Concurrent Ethanol and Saccharin Consumption on Sperm Parameters in Adult Mice
Background: Since sperm parameters have a critical role in reproductive function, the objective of this study was to evaluate the effects of concomitant ethanol and saccharin consumption on sperm parameters in adult mice. Chronic ethanol consumption suppresses male reproductive function and sexual behavior in laboratory animals and humans. Furthermore, alcohol abuse by males has been correlated...
متن کاملEffect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
The effect of ulcérationof the urinary bladder on bladder carcinogenesis induced by W-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or sodium saccharin was evaluated in 5week-old F344 rats which were all killed 2 years after the start of the experiment. The results indicate that long-term feeding of sodium saccharin, a nonmutagen, appears to be capable of inducing bladder tumors if admini...
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The ability to predict harmful effects of chemicals, drugs, and food additives has historically depended on the process of extrapolating from animal studies. The current guidelines of the U.S. Food and Drug Administration recommend nine animalbased studies to assess the safety of additives used directly in food handling or preparation or at the table in amounts in excess of 1 part per million i...
متن کاملEffect of Regenerative Hyperplasia on the Urinary Bladder: Carcinogenicity of Sodium Saccharin and N-[4-(5-Nitro-2- furyl)-2-thiazolyl]formamide1
The effect of ulcérationof the urinary bladder on bladder carcinogenesis induced by W-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or sodium saccharin was evaluated in 5week-old F344 rats which were all killed 2 years after the start of the experiment. The results indicate that long-term feeding of sodium saccharin, a nonmutagen, appears to be capable of inducing bladder tumors if admini...
متن کاملDo sweetening agents interact with morphine-induced analgesia in the formalin test in mice?
There is evidence that sweeteners such as sucrose and saccharin interact with endogenous opioid systems. Further research has shown that feeding different concentrations of sucrose and saccharin alter latency in the tail-flick test. In this study, the influence of a 12-day regimen of different sweetening agents, sucrose (32%), saccharin (0.08%) and aspartame (0.16%) on morphine-induced analge...
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تاریخ انتشار 2003